منابع مشابه
Prions.
The discovery of infectious proteins, denoted prions, was unexpected. After much debate over the chemical basis of heredity, resolution of this issue began with the discovery that DNA, not protein, from pneumococcus was capable of genetically transforming bacteria (Avery et al. 1944). Four decades later, the discovery that a protein could mimic viral and bacterial pathogens with respect to the ...
متن کاملPrions.
Infectious proteins (prions) are usually self-templating filamentous protein polymers (amyloids). Yeast prions are genes composed of protein and, like the multiple alleles of DNA-based genes, can have an array of "variants," each a distinct self-propagating amyloid conformation. Like the lethal mammalian prions and amyloid diseases, yeast prions may be lethal, or only mildly detrimental, and sh...
متن کاملPrions
plants are cloaked in hundreds of tiny projections, known as trichomes. These structures vary in function, shape, size and spacing from species to species, and it’s not known whether similar cellular differentiation programs are responsible for making trichomes in different plants. Trichomes are clearly visible in the scanning electron micrograph of a wild-type Nicotiana tabacum seedling above ...
متن کاملAnimal Prions Are a New Type of Infectious Agents Prions
Prions were originally defined as infectious agents of protein nature, which caused neurodegenerative diseases in animals and humans. The prion concept implies that the infectious agent is a protein in special conformation that can be transmitted to the normal molecules of the same protein through protein–protein interactions. Until the 1990s, the prion phenomenon was associated with the single...
متن کاملProtein-only prions
Bugs to the rescue ugs that live in our gut are not only not harmful but provide signals that maintain gut tissue integrity, according to Seth Rakoff-Nahoum, Ruslan Medzhitov, and colleagues (Yale University, New Haven, CT). The benefits of commensal, or nonpathogenic gut bacteria, are well known. For example, these bacteria digest tricky carbohydrates and supply certain micronutrients. But ina...
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ژورنال
عنوان ژورنال: Nature Reviews Neuroscience
سال: 2003
ISSN: 1471-003X,1471-0048
DOI: 10.1038/nrn1020